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A defect in the sterol:steryl ester interconversion in a mutant of the yeast, Saccharomyces cerevisiae
G A Keesler1, S M Laster, L W Parks
1Department of Microbiology, North Carolina State University, Raleigh 27695-7615.
Biochimica Et Biophysica Acta
|January 24, 1992
Abstract:
A culture cycle dependent interconversion of sterols and steryl esters is disturbed in a mutant of Saccharomyces cerevisiae. Independent extragenic suppressors to this mutant return the mutant's pleiotropic phenotype to that of the parental wild type. Concomitant with the alterations in interconversion, modifications were found in the yeast proteins that antigenically react with antibodies elicited against mammalian apolipoproteins. Suppressor mutations returned the aberrant immunoblot banding pattern of the mutant to that of the wild type in apolipoprotein B.