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Updated: Jul 16, 2026
07:06
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
[Clostridium difficile associated diarrhea in the elderly patient].
T Pareja Sierra1, M Hornillos Calvo
1Sección de Geriatría, Hospital Universitario de Guadalajara, Spain. tparejas2@hotmail.com
Revista Clinica Espanola
|April 3, 2007
Summary
Clostridium difficile infections cause significant nosocomial diarrhea in the elderly, often linked to antibiotic use. Early diagnosis and preventive measures are crucial to manage this potentially severe condition and its frequent recurrences.
Area of Science:
- Infectious Diseases
- Gastroenterology
- Epidemiology
Background:
- Clostridium difficile is a primary cause of hospital-acquired diarrhea in older adults.
- The infection can lead to colitis and extraintestinal complications.
- Prolonged antibiotic use in elderly patients with severe underlying conditions is a major risk factor.
Purpose of the Study:
- To summarize the epidemiology, diagnosis, treatment, and prevention of Clostridium difficile infections.
- To highlight the challenges posed by recurrent infections and emerging virulent strains.
Main Methods:
- Diagnosis relies on stool culture and toxin detection assays.
- Treatment involves antibiotic withdrawal, supportive care, and potentially metronidazole or vancomycin.
- Preventive strategies focus on interrupting transmission routes.
Main Results:
- Clostridium difficile infections are a leading cause of nosocomial diarrhea in the elderly.
- Recurrence rates can be as high as 20%.
- New, more virulent strains are increasing the disease's impact.
Conclusions:
- Effective management requires prompt diagnosis and appropriate treatment.
- Preventing the spread through healthcare personnel and instruments is essential.
- The emergence of virulent strains necessitates ongoing vigilance and research.
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