Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lymphoma in inflammatory bowel disease.

A J Greenstein1, G E Mullin, J A Strauchen

  • 1Department of Surgery, Mount Sinai School of Medicine, City University of New York, New York.

Cancer
|March 11, 1992
PubMed
Summary

Patients with inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), have an increased risk of developing lymphoma. This study highlights the occurrence and characteristics of these associated malignancies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surgical solutions for refractory J-pouch inlet obstruction.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2019
Same author

The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data.

BMC complementary and alternative medicine·2019
Same author

Obesity increases the risk of small intestinal bacterial overgrowth (SIBO).

Neurogastroenterology and motility·2017
Same author

Recurrence of Crohn's disease in end ileostomies.

Inflammatory bowel diseases·2013
Same author

Inflammatory bowel disease mucosal biopsies have specialized lymphokine mRNA profiles.

Inflammatory bowel diseases·2013
Same author

Crohn's disease: to lump or to split?

Inflammatory bowel diseases·2013

Area of Science:

  • Gastroenterology and Oncology
  • Inflammatory Bowel Disease (IBD) Complications
  • Lymphoma Epidemiology

Background:

  • Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), is associated with an increased risk of certain cancers.
  • Lymphoma development in IBD patients is a recognized but less common complication requiring further investigation.
  • Understanding the specific risk factors and presentation of lymphoma in IBD is crucial for patient management.

Purpose of the Study:

  • To report on the incidence and characteristics of lymphoma in patients with ulcerative colitis (UC) and Crohn's disease (CD).
  • To analyze the demographic and clinical features of lymphoma associated with IBD.
  • To compare the latency and presentation of lymphoma in UC versus CD patients.

Main Methods:

Related Experiment Videos

  • Retrospective review of nine patients diagnosed with lymphoma and IBD between 1960 and 1983 at The Mount Sinai Hospital.
  • Analysis of patient demographics, IBD type (UC or CD), age at IBD onset, age at lymphoma diagnosis, and lymphoma location.
  • Comparison of disease duration and latency periods for lymphoma development in UC and CD cohorts.

Main Results:

  • Five lymphomas occurred in 1156 UC patients (0.43%) and four in 1480 CD patients (0.27%).
  • Lymphomas were predominantly extraintestinal in both UC (4/5) and CD (4/4) patients.
  • UC-associated lymphomas occurred later in life with shorter disease duration compared to CD-associated lymphomas, which presented earlier with longer disease duration.

Conclusions:

  • Patients with IBD, particularly CD, exhibit a male predominance for associated lymphomas.
  • The risk factors for colonic lymphoma in IBD patients resemble those for colitis-associated colorectal carcinoma.
  • The occurrence of colonic carcinoma within the first decade of colitis and the development of a second malignancy in UC patients warrant further attention.