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Updated: Jul 15, 2026

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
Published on: March 7, 2025
Early impairment of synaptic plasticity in patients with Down's syndrome
Fortunato Battaglia1, Angelo Quartarone, Vincenzo Rizzo
1CUNY School of Medicine, Department of Physiology and Pharmacology, 138th Street & Convent Avenue, Room D-210, New York, NY 10031, United States. fb@med.cuny.edu
Abstract:
We investigated synaptic plasticity in persons with Down' syndrome (DS) and control subjects used paired associative stimulation (PAS) protocol, a paradigm capable of producing long-term potentiation (LTP)-like changes in the sensorimotor system. After PAS, patients showed less LTP-like plasticity compared to control subjects. Abnormal motor cortex synaptic plasticity may play a role in the development of motor signs in DS.
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