Related Experiment Video
Updated: Jul 15, 2026

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens
Published on: February 14, 2011
Prostaglandin E2 inhibits Paracoccidioides brasiliensis killing by human monocytes
Ana Paula Bordon1, Luciane Alarcão Dias-Melicio, Michele Janegitz Acorci
1Department of Microbiology and Immunology, Institute of Biosciences, São Paulo State University - UNESP, Botucatu, CEP: 18618-000 Sao Paulo, Brazil.
Abstract:
Human monocytes lacked fungicidal activity against high virulence strain of Paracoccidioides brasiliensis, even after IFN-gamma activation. However, monocytes treated with indomethacin exhibited an effective killing against this fungus, suggesting a role of prostaglandin E2 (PGE2) in the inhibition process. Thus, the purpose of this work was to determine whether the effect of PGE2 in fungicidal activity was related with decrease on H(2)O(2) release, the metabolite involved in P. brasiliensis killing, and changes in the levels of TNF-alpha, IL-6 and IL-10. Human monocytes challenged with the fungus produced high PGE2 levels, which in turn inhibited the fungicidal activity of these cells by reducing H(2)O(2) and TNF-alpha production.
Related Concept Videos
Antiprotozoal Agents
Antifungal Agents
Cryptococcal Meningitis
Anthelminthic Agents

