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Automated Counterflow Centrifugal System for Small-Scale Cell Processing
Published on: December 12, 2019
Design of simulated moving bed processes under reduced purity requirements
Malte Kaspereit1, Andreas Seidel-Morgenstern, Achim Kienle
1Max-Planck-Institut für Dynamik komplexer technischer Systeme, D-39106 Magdeburg, Germany. kaspereit@mpi-magdeburg.mpg.de
Journal of Chromatography. A
|April 3, 2007
Summary
This study optimizes simulated moving bed chromatography design by treating internal flow rates as free parameters. Non-restrictive designs significantly improve process performance and offer a simple method for achieving desired outlet purity.
Area of Science:
- Chemical Engineering
- Separation Science
- Chromatography
Background:
- Simulated Moving Bed (SMB) chromatography is a continuous chromatographic separation technique.
- Process design often involves optimizing flow rates for efficiency.
Purpose of the Study:
- Investigate SMB chromatography design under relaxed purity constraints.
- Develop a simplified design method based on equilibrium theory.
Main Methods:
- Parametric study of internal flow rates.
- Numerical optimization of two distinct design scenarios (restrictive vs. non-restrictive).
Main Results:
- Internal flow rates are critical free parameters in SMB process design.
- Non-restrictive designs, optimizing all flow rates, yield significantly improved performance.
- A straightforward design method for target outlet purity was derived.
Conclusions:
- Optimizing flow rates in SMB chromatography enhances process performance.
- Relaxed purity requirements allow for more efficient SMB process designs.
- The derived method simplifies the design of SMB processes.
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