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Related Experiment Video

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Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
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Ovine fetal necrobacillosis.

J S Agerholm1, M Boye, B Aalbaek

  • 1Department of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark. jager@life.ku.dk <jager@life.ku.dk>

Journal of Comparative Pathology
|April 3, 2007
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Fusobacterium necrophorum, a bacterium previously unrecognized in sheep abortions, was identified using fluorescence in-situ hybridization (FISH). This study highlights its role in late-term ovine abortions and emphasizes diagnostic methods beyond traditional culturing.

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Area of Science:

  • Veterinary Pathology
  • Microbiology
  • Ovine Reproduction

Background:

  • Fusobacterium necrophorum is a Gram-negative anaerobic bacterium.
  • Ovine abortion can result from various infectious agents.
  • The role of F. necrophorum in sheep abortions was previously uncharacterized.

Purpose of the Study:

  • To investigate the association of Fusobacterium necrophorum with late-term ovine abortions.
  • To characterize the pathological findings associated with F. necrophorum infection in sheep.
  • To evaluate the utility of culture-independent diagnostic methods for identifying F. necrophorum.

Main Methods:

  • Bacterial identification using fluorescence in-situ hybridization (FISH) with a specific 16S rRNA probe.
  • Gross and histological examination of placental and fetal tissues.
  • Analysis of lesions including neutrophil infiltration, necrosis, and thrombosis.

Main Results:

  • Fusobacterium necrophorum was identified in five cases of ovine abortion.
  • Placental lesions showed suppurative inflammation, necrosis, and thrombosis.
  • Infection spread to fetuses via haematogenous dissemination (necrotizing hepatitis) or through amniotic fluid (dermatitis, bronchopneumonia).
  • FISH-positive bacteria were localized at the periphery of necrotic lesions.

Conclusions:

  • Fusobacterium necrophorum is identified as a causative agent of late-term abortion in sheep.
  • The study underscores the importance of culture-independent diagnostic techniques, such as FISH, for identifying non-culturable bacteria.
  • This finding expands the known spectrum of ovine abortion pathogens.