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Updated: Jul 15, 2026
An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers
Published on: December 1, 2017
Antibody titer in Iranian children 6 years after hepatitis B vaccine administration
Salehi Hassan1, Farajzadegan Ziba
1Isfahan Medical University, Iran.
Insights
Hepatitis B virus (HBV) vaccination in children shows variable antibody levels at age six. High-risk children may need monitoring and booster shots to ensure sustained immunity.
Area of Science:
- Pediatric Immunology
- Vaccinology
- Hepatitis B Research
Background:
- Hepatitis B virus (HBV) infant immunization is crucial for preventing infection.
- The long-term efficacy and duration of protection afforded by the HBV vaccine remain largely unknown.
Purpose of the Study:
- To assess the immune response in children vaccinated against HBV.
- Evaluate antibody levels in 6-year-old children who received routine HBV vaccination.
Main Methods:
- Antibody levels (anti-HBs) were measured in 3752 children vaccinated in Iran.
- Immune status was determined based on antibody titers.
- Statistical analysis compared immune and non-immune groups and identified predictors of antibody levels.
Main Results:
- 19.3% of children had antibody levels below 10 MIU/mL, indicating potential non-immunity.
- 29.2% had levels of 100 MIU/mL or higher, suggesting robust immunity.
- Geometric Mean Titer (GMT) was 34.5 MIU/mL; significant differences were observed between immune and non-immune children.
- Low birth weight and chronic disease were identified as predictors of antibody levels.
Conclusions:
- Regular monitoring of anti-HBs is recommended for high-risk children.
- Booster vaccinations should be administered as needed to maintain adequate protection against HBV.
Objective:
The purpose of study was to evaluate the immune response in a sample of vaccinated children aged 6 years.
Background:
Although immunization of infants against hepatitis B virus (HBV) is the most effective way to prevent infection, duration of the afforded immunization is unknown.
Methods:
The immunity derived from the HBV vaccine was assessed by measuring the antibody in 3752 children who were vaccinated in a routine vaccination program in three cities of Iran (Isfahan, Khoramabad, Shahrekord).
Results:
Seven hundred and twenty-three (19.3%) children had antibodies levels <10 MIU/mL and 1096 (29.2%) had antibodies levels >or=100 MIU/mL. The total GMT was 34.5+/-0.66, and GMT was statistically different in non-immune and immune children (3.1+/-0.36 versus 49.1+/-0.52). No correlation was found between HbsAb titers and growth pattern during the first and sixth years of life, number of vaccine, time of vaccination and drug use. The predictors were low birth weight and chronic disease.
Conclusion:
It is recommended that high risk children should be monitored regularly for anti-HBS, and booster must be administrated, if necessary.
