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Online resources for SNP analysis: a review and route map
1The Spanish National Genotyping Centre CeGen, Santiago node, Genomic Medicine Group, University of Santiago de Compostela, Galicia, Spain. c.phillips@mac.com
This review compares major online single nucleotide polymorphism (SNP) databases, like NCBI dbSNP and HapMap, to guide genetic analysis. It provides search strategies and tools for clinical and population genetics research.
Area of Science:
- Genetics
- Bioinformatics
Background:
- Single nucleotide polymorphisms (SNPs) are crucial genetic markers.
- Online databases are essential resources for genetic analysis.
- Accessibility and utility of these databases vary.
Purpose of the Study:
- To review and compare major online SNP databases.
- To provide guidance on effective search strategies for genetic research.
- To detail tools for designing SNP genotyping assays.
Main Methods:
- Comparative review of publicly available SNP databases.
- Explanation of search functionalities within NCBI dbSNP and HapMap.
- Description of online SNP assay design tools.
Main Results:
- Key features and differences of major SNP databases are highlighted.
- Effective search strategies for clinical and population genetics are outlined.
- Useful online tools for genotyping assay design are presented.
Conclusions:
- Informed selection of SNP databases enhances genetic research efficiency.
- Understanding search strategies optimizes data retrieval.
- Available tools support the design of robust SNP genotyping assays.
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