Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Lipid Catabolism01:25

Lipid Catabolism

Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Lipid Absorption01:24

Lipid Absorption

Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal Colonization, Perinatal Exposure, and Neonatal Acquisition of Resistant Enterobacterales.

Open forum infectious diseases·2026
Same author

16-O-methylcafestol is present in ground roast Arabica coffees: Implications for authenticity testing.

Food chemistry·2018
Same author

Species Determination and Quantitation in Mixtures Using MRM Mass Spectrometry of Peptides Applied to Meat Authentication.

Journal of visualized experiments : JoVE·2016
Same author

Low-field (1)H NMR spectroscopy for distinguishing between arabica and robusta ground roast coffees.

Food chemistry·2016
Same author

Meat Authentication via Multiple Reaction Monitoring Mass Spectrometry of Myoglobin Peptides.

Analytical chemistry·2015
Same author

Dysfunctional HDL and atherosclerotic cardiovascular disease.

Nature reviews. Cardiology·2015

Related Experiment Videos

HDL function as a target of lipid-modifying therapy.

Karol E Watson1, Benjamin J Ansell, Andrew D Watson

  • 1Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Reviews in Cardiovascular Medicine
|April 3, 2007
PubMed
Summary

High-density lipoprotein (HDL) can become pro-inflammatory, contributing to atherosclerosis. Therapies targeting HDL show promise in modifying its function, but clinical outcomes vary, necessitating further research into HDL

Related Experiment Videos

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Inflammation Biology

Background:

  • High-density lipoprotein (HDL) is traditionally viewed as atheroprotective.
  • However, HDL can adopt pro-inflammatory properties under specific conditions.
  • These functional shifts impact vascular inflammation, lipid oxidation, and thrombosis.

Purpose of the Study:

  • To explore the dual nature of HDL, encompassing both anti-inflammatory and pro-inflammatory roles.
  • To review methods for assessing HDL's functional properties.
  • To discuss the impact of systemic inflammation, metabolic syndrome, and therapeutic interventions on HDL functionality.

Main Methods:

  • Assessment of HDL's functional properties using cell-based and cell-free assays.
  • Review of clinical studies investigating HDL-modifying agents.
  • Analysis of factors influencing HDL's anti-inflammatory versus pro-inflammatory capacity.

Main Results:

  • Systemic inflammation and metabolic syndrome tend to induce pro-inflammatory HDL.
  • Statins and apolipoprotein A-1 mimetics can enhance HDL's anti-inflammatory characteristics.
  • Fibrates and niacin improved outcomes in patients with low HDL-C and risk factors, though not universally.

Conclusions:

  • HDL's atherogenic or atheroprotective potential is determined by its composition and functional state.
  • Therapeutic strategies targeting HDL modification require careful consideration of individual patient factors and specific HDL properties.
  • Further research is needed to optimize HDL-targeted therapies for cardiovascular disease prevention.