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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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Long-term renal function following bone marrow transplantation.

M H Grönroos1, P Bolme, J Winiarski

  • 1Department of Pediatrics, Turku University Central Hospital, Turku, Finland.

Bone Marrow Transplantation
|April 3, 2007
PubMed
Summary

Bone marrow transplantation (BMT) can impair kidney function, significantly reducing glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) in children. Total body irradiation (TBI) is a key risk factor for chronic renal impairment.

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Area of Science:

  • Pediatric Nephrology
  • Hematology
  • Oncology

Background:

  • Bone marrow transplantation (BMT) is a crucial treatment for various pediatric conditions.
  • Long-term effects of BMT on renal function in children are not fully understood.
  • Assessing kidney function post-BMT is vital for patient outcomes.

Purpose of the Study:

  • To evaluate long-term renal function in pediatric patients after allogeneic or autologous BMT.
  • To identify risk factors associated with chronic renal impairment post-BMT.
  • To compare renal function across different BMT patient groups and healthy controls.

Main Methods:

  • Prospective study of 187 pediatric patients undergoing BMT (allogeneic and autologous).
  • Measurement of glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) at various time points.
  • Comparison with 50 healthy pediatric controls; analysis of conditioning therapies including total body irradiation (TBI).

Main Results:

  • GFR and ERPF were normal pre-BMT but significantly reduced at 1 year post-BMT.
  • GFR showed slight recovery by 3 years, while ERPF recovery was not observed.
  • Chronic renal impairment affected 41% at 1 year, decreasing to 11% by 7 years; TBI was the primary risk factor.

Conclusions:

  • BMT leads to significant, long-lasting renal function impairment in pediatric patients.
  • Total body irradiation (TBI) is a critical risk factor for developing chronic kidney issues post-BMT.
  • Routine renal function monitoring is recommended for pediatric BMT survivors.