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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...

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Related Experiment Video

Updated: Jul 15, 2026

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

Targeting the stem cell niche: squeezing blood from bones.

K Ballen1

  • 1Division of Hematology/Oncology, Massachusetts General Hospital, Boston, MA 02214, USA. kballen@partners.org

Bone Marrow Transplantation
|April 3, 2007
PubMed
Summary

Stem cell niches regulate stem cell proliferation and function. Targeting osteoblasts or calcium receptors with drugs like parathyroid hormone (PTH) may improve stem cell mobilization and engraftment.

Area of Science:

  • Stem Cell Biology
  • Hematopoiesis
  • Microenvironment Biology

Background:

  • Stem cells reside in specialized niches that control their proliferation and function.
  • The stem cell niche microenvironment influences stem cell behavior and offers therapeutic targets.
  • Osteoblasts and calcium sensing receptors play key roles in regulating stem cell niches.

Purpose of the Study:

  • To review the biology of the stem cell niche.
  • To explore potential therapeutic manipulations of the stem cell niche for improving stem cell function.
  • To discuss the role of parathyroid hormone (PTH) in stem cell mobilization and engraftment.

Main Methods:

  • Review of existing literature on stem cell niche biology.
  • Analysis of the role of osteoblasts and calcium sensing receptors in stem cell regulation.

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Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
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Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
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Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

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Last Updated: Jul 15, 2026

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
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Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
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Combining Intravital Fluorescent Microscopy (IVFM) with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

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Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
10:32

Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

  • Examination of clinical trial data for PTH in stem cell transplantation.

    • Main Results:

    • The stem cell niche regulates stem cell proliferation and function through interactions with surrounding cells like osteoblasts.
    • Targeting calcium sensing receptors on hematopoietic stem cells can potentially increase stem cell numbers.
    • Parathyroid hormone (PTH) is being investigated for its efficacy in improving stem cell mobilization and engraftment.

    Conclusions:

    • Understanding stem cell niche biology is crucial for developing novel therapeutic strategies.
    • Pharmacological targeting of the stem cell niche, particularly using agents like PTH, shows promise for enhancing stem cell transplantation outcomes.
    • Further research and clinical trials are needed to fully elucidate the therapeutic potential of manipulating the stem cell niche.