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Effect of hyperoxia on cortical neuronal nuclear function and programmed cell death mechanisms

Eddie Chang1, Kristie Hornick, Karen I Fritz

  • 1Department of Pediatrics, St. Christopher's Neonatal Research, Drexel University College of Medicine, 245 N. 15th Street, Mail Stop 1029, New College Building, Room 7402, Philadelphia, PA 19102, USA. eddiechangmd@yahoo.com

Neurochemical Research
|April 3, 2007
PubMed
Summary

High oxygen levels (hyperoxia) harm newborn piglets' brains by damaging neuronal nuclear membranes, increasing calcium influx, and promoting cell death. This study reveals mechanisms behind oxygen-induced neurotoxicity in developing brains.

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