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Updated: Jul 15, 2026

Size Matters: Measurement of Capsule Diameter in Cryptococcus neoformans

Size Matters: Measurement of Capsule Diameter in Cryptococcus neoformans

Published on: February 27, 2018

Non-neoformans cryptococcal infections: a systematic review.

T Khawcharoenporn¹, A Apisarnthanarak, L M Mundy

¹Division of Infectious Diseases, Faculty of Medicine, Thammasart University Hospital, Pratumthani, 12120, Thailand. anapisarn@yahoo.com

|April 3, 2007

Summary

Non-neoformans cryptococcal infections, often caused by Cryptococcus laurentii and Cryptococcus albidus, are increasingly reported. Invasive devices and impaired immunity are risk factors, necessitating a high index of suspicion for early diagnosis and treatment.

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Last Updated: Jul 15, 2026

Size Matters: Measurement of Capsule Diameter in Cryptococcus neoformans

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Published on: February 27, 2018

Assessing the Putative Anticryptococcal Properties of Crude and Clarified Extracts from Mollusks

Assessing the Putative Anticryptococcal Properties of Crude and Clarified Extracts from Mollusks

Published on: December 2, 2022

Area of Science:

Medical Mycology
Infectious Diseases
Clinical Microbiology

Background:

Non-neoformans cryptococci, previously considered harmless saprophytes, are emerging as significant human pathogens.
Cryptococcus laurentii and Cryptococcus albidus account for 80% of non-neoformans cryptococcal infections.
Impaired cell-mediated immunity and prior azole prophylaxis are identified risk factors.

Purpose of the Study:

To investigate the epidemiology and risk factors associated with non-neoformans cryptococcal infections.
To identify predictors of mortality in patients with non-neoformans cryptococcal infections.
To emphasize the importance of early diagnosis and treatment due to overlapping clinical presentations with Cryptococcus neoformans.

Main Methods:

Retrospective analysis of clinical data from patients with non-neoformans cryptococcal infections.
Statistical analysis including adjusted odds ratios (aOR) and confidence intervals (CI) to determine risk factors and mortality predictors.
Comparison of clinical manifestations with Cryptococcus neoformans infections.

Main Results:

The presence of invasive devices was a significant risk factor for Cryptococcus laurentii infection (aOR = 8.7).
Mortality predictors included age ≥45 years (aOR = 8.4) and meningeal presentation (aOR = 7.0).
Clinical presentations are often indistinguishable from Cryptococcus neoformans infections.

Conclusions:

Non-neoformans cryptococci represent a growing threat, particularly in immunocompromised individuals and those with invasive devices.
Prompt diagnosis and treatment are crucial, requiring a high index of suspicion due to non-specific clinical signs.
Further research into optimal management strategies for these emerging fungal infections is warranted.