Related Experiment Videos
[Spontaneous cleft palate in CF#1/Ohu mice].
Y Matsushima1, M Ohne, T Irino
1Department of Laboratory Animal Science, Ohu University, School of Dentistry, Fukushima, Japan.
Jikken Dobutsu. Experimental Animals
|January 1, 1992
Summary
Researchers identified spontaneous cleft palate in CF#1 mice, distinct from other models. This finding suggests CF#1 mice are valuable for genetic and biochemical cleft palate research.
Area of Science:
- Developmental Biology
- Genetics
- Animal Models
Context:
- Cleft palate is a common congenital condition.
- Existing animal models like A/J and CL/Fr strains have limitations.
- Spontaneous mutations offer insights into developmental processes.
Purpose:
- To report the discovery of spontaneous cleft palate in CF#1 mice.
- To characterize the frequency and phenotype of cleft palate in CF#1 strains.
- To evaluate CF#1 mice as novel models for cleft palate research.
Summary:
- Spontaneous cleft palate was observed in CF#1/Ohu mice.
- Frequencies of approximately 3% were noted in CF#1/Jms and CF#1/Jah strains.
- The observed cleft palate characteristics in CF#1 mice differ significantly from established models.
Impact:
- CF#1 mice represent a new resource for studying the genetic and biochemical underpinnings of cleft palate.
- This discovery may facilitate the development of targeted therapies.
- Further research using CF#1 models can elucidate complex etiological factors.