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CA-125 levels in human uterine fluid.

M Abaé1, M Gibson, J Chapitis

  • 1Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington.

Fertility and Sterility
|March 1, 1992
PubMed
Summary

Uterine fluid CA-125 (cancer antigen 125) concentrations are high and stable throughout the menstrual cycle. Unlike serum CA-125, uterine fluid levels do not fluctuate between the follicular and luteal phases.

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Area of Science:

  • Gynecology
  • Reproductive Endocrinology
  • Biochemistry

Background:

  • CA-125 (cancer antigen 125) is a tumor marker often monitored in gynecological conditions.
  • Understanding CA-125 dynamics in the female reproductive tract is crucial for accurate interpretation of its levels.

Purpose of the Study:

  • To quantify uterine fluid CA-125 concentrations.
  • To investigate potential phase-dependent variations of uterine fluid CA-125 during the menstrual cycle.
  • To compare uterine fluid CA-125 levels with concurrent serum CA-125 levels.

Main Methods:

  • CA-125 levels were measured in uterine fluid collected during the follicular and luteal phases of the menstrual cycle.
  • Paired uterine fluid and serum samples were obtained sequentially in the midfollicular and midluteal phases.

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  • Statistical analysis was performed to compare levels between phases and between fluids.

    • Main Results:

    • Uterine fluid CA-125 concentrations were significantly higher than serum levels, with a wider range observed.
    • Follicular phase uterine fluid CA-125 ranged from 16.4 x 10(3) to 616.5 x 10(3) U/mL.
    • Luteal phase uterine fluid CA-125 ranged from 6.2 x 10(3) to 567.3 x 10(3) U/mL, showing no significant difference from the follicular phase (P = 0.75).
    • Serum CA-125 levels showed a significant increase in the midluteal phase (P < 0.05).

    Conclusions:

    • Uterine fluid exhibits high concentrations of CA-125.
    • CA-125 levels in uterine fluid remain relatively stable and do not fluctuate significantly between the follicular and luteal phases of the menstrual cycle.
    • These findings highlight distinct dynamics of CA-125 in uterine fluid compared to serum.