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Updated: Jul 15, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
Alkaloids from Corydalis bulbosa
H G Kiryakov1, E Iskrenova, B Kuzmanov
1Department of Chemistry, High Medical Institute, Plovdiv, Bulgaria.
Abstract:
A new 4,5-dioxoaporphine, named corydione, was isolated from the whole herb of Corydalis bulbosa (L.) Dc (Papaveraceae), together with dehydronantenine, (-)-stylopine, (+)-bicuculline, (-)-adlumidine, (+)-nantenine, (+)-bulbocapnine, protopine (-)-domesticine, (+)-corydine, predicentrine, oxonantenine, (+)-isoboldine and nandazurine. Glaucine and thaliporphine were detected by means of thin-layer chromatography. In addition, one minor alkaloid Cb-4, uncompletely identified, was described. The spectral data of corydione, predicentrine and nandazurine are given.
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