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Further alkaloids from Strychnos dolichothyrsa.

R Verpoorte¹, M J Verzijl, A B Svendsen

¹Department of Pharmacognosy, Gorlaeus Laboratories, Leiden, The Netherlands.

|January 1, 1982

Summary

Researchers isolated alkaloids from Strychnos dolichothyrsa stem bark, identifying bisnor-C-alkaloid H as the major compound. Two new dimeric alkaloids, dolichocurine and dolichothine, were discovered, along with eleven minor alkaloids.

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Area of Science:

Phytochemistry
Natural Product Chemistry
Organic Chemistry

Background:

The Strychnos genus is a rich source of bioactive alkaloids.
Previous research has indicated the presence of diverse alkaloid profiles in Strychnos species.

Purpose of the Study:

To isolate and characterize alkaloids from the stem bark of Strychnos dolichothyrsa.
To identify novel alkaloid structures and expand the known chemical diversity of Strychnos species.

Main Methods:

Extraction of alkaloids from Strychnos dolichothyrsa stem bark.
Chromatographic separation techniques for isolating individual alkaloids.
Spectroscopic methods (e.g., NMR, Mass Spectrometry) for structure elucidation.

Main Results:

Isolation of one major alkaloid, bisnor-C-alkaloid H.
Discovery and characterization of two new dimeric alkaloids: dolichocurine and dolichothine, derived from bisnor-C-alkaloid H.
Identification of eleven minor alkaloids, including Wieland Gumlich aldehyde and 11-methoxy-diaboline.
11-methoxy-diaboline was also identified as a major alkaloid in Strychnos urceolata.

Conclusions:

The stem bark of Strychnos dolichothyrsa contains a complex mixture of alkaloids, including novel dimeric compounds.
The structural elucidation of dolichocurine and dolichothine contributes to the understanding of alkaloid biosynthesis and chemical diversity in Strychnos.
This study expands the repertoire of known Strychnos alkaloids and highlights the potential of these plants as sources for new natural products.