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Updated: Jul 15, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
Further alkaloids from Strychnos dolichothyrsa
R Verpoorte1, M J Verzijl, A B Svendsen
1Department of Pharmacognosy, Gorlaeus Laboratories, Leiden, The Netherlands.
Abstract:
The isolation of one of the major alkaloids and 11 minor alkaloids from the stem bark of Strychnos dolichothyrsa is described. The major alkaloid was identified as bisnor-C-alkaloid H. Two new dimeric alkaloids derived from this alkaloid were found, dolichocurine and dolichothine. For the former alkaloid a structure is proposed. Furthermore, the following minor alkaloids were identified: bisnor-C-alkaloid H N-oxide and di-N-oxide, Wieland Gumlich aldehyde, 18-deoxy Wieland Gumlich aldehyde, 11-methoxy-diaboline, tubotaiwine, condylocarpine, nor-C-fluorocurarine and nor-macusine B. In the extracts of the stem bark of S. urceolata 11-methoxydiaboline was identified as one of the major alkaloids.
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