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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

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Related Experiment Video

Updated: Jul 15, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis
08:49

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

Perianal Crohn's disease.

Marat Khaikin1, Yehuda Chowers, Oded Zmora

  • 1Department of Surgery, Sheba Medical Center, Tel Hashomer, Israel.

The Israel Medical Association Journal : IMAJ
|April 4, 2007
PubMed
Summary

Perianal Crohn's disease, affecting the anal region, often involves abscesses and fistulas, significantly impacting quality of life. Treatment combines medical and surgical approaches for improved patient outcomes.

Area of Science:

  • Gastroenterology
  • Colorectal Surgery
  • Inflammatory Bowel Disease Research

Background:

  • Perianal Crohn's disease involves the anal region in Crohn's disease, a chronic inflammatory bowel condition.
  • Common presentations include perianal abscesses, fistulas, fissures, and skin tags.
  • Disease activity in the perianal region impacts patient quality of life and can be independent of abdominal disease.

Purpose of the Study:

  • To review contemporary management strategies for perianal Crohn's disease.
  • To highlight the importance of a multidisciplinary approach in treating this condition.
  • To discuss current and emerging medical and surgical treatment options.

Main Methods:

  • Review of current medical literature on perianal Crohn's disease management.

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Murine Ileocolic Bowel Resection with Primary Anastomosis
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  • Focus on established and novel therapeutic interventions.
  • Emphasis on integrated care involving various medical specialists.

    • Main Results:

    • Perianal Crohn's disease requires a combined medical and surgical approach.
    • Successful treatment necessitates a multidisciplinary team.
    • Contemporary treatments include infliximab, endorectal advancement flap, fibrin glue, and extracellular matrix plugs.

    Conclusions:

    • Effective management of perianal Crohn's disease relies on a comprehensive, multidisciplinary strategy.
    • Medical and surgical interventions are crucial for improving patient quality of life.
    • Emerging therapies offer new possibilities for treating complex perianal manifestations.