Jove
Visualize
Contact Us

Related Experiment Videos

Sample preparation in lab-on-a-chip systems.

K S Drese1, F von Germar, M Ritzi

  • 1Fluidics and Simulation Department, Institut für Mikrotechnik Mainz GmbH, Mainz, Germany.

Medical Device Technology
|April 4, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hands-free sample preparation platform for nucleic acid analysis.

Lab on a chip·2009
Same author

Electrophoretic partitioning of proteins in two-phase microflows.

Lab on a chip·2006
Same author

Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus.

The EMBO journal·2001
Same author

Immunohistochemical detection of cell growth fraction in formalin-fixed and paraffin-embedded murine tissue.

The American journal of pathology·2001
Same author

The human origin recognition complex protein 1 dissociates from chromatin during S phase in HeLa cells.

The Journal of biological chemistry·2000
Same author

Initiation of genome replication: assembly and disassembly of replication-competent chromatin.

Gene·2000
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Fully integrated lab-on-chip systems for deoxyribonucleic acid (DNA) analysis are uncommon. This article proposes combining modules to create a comprehensive DNA analysis system.

Area of Science:

  • Biotechnology
  • Analytical Chemistry
  • Microfluidics

Background:

  • Fully integrated lab-on-chip (LOC) systems are scarce in current scientific practice.
  • No existing LOC system fully replicates the capabilities of a traditional laboratory.
  • Deoxyribonucleic acid (DNA) analysis often requires complex, multi-step laboratory procedures.

Purpose of the Study:

  • To outline strategies for creating a fully integrated LOC system.
  • To focus on the specific application of deoxyribonucleic acid (DNA) analysis.
  • To address the limitations of current single-module LOC devices.

Main Methods:

  • Conceptual framework for module integration.
  • Review of existing single-module LOC technologies.

Related Experiment Videos

  • System design principles for DNA analysis on-chip.

    • Main Results:

    • A proposed approach for combining discrete LOC modules.
    • Identification of key modules for comprehensive DNA analysis.
    • Demonstration of feasibility for integrated DNA analysis.

    Conclusions:

    • Combining specific single modules offers a viable pathway to fully integrated LOC systems.
    • Integrated LOC systems can enhance efficiency and accessibility for DNA analysis.
    • Further development is needed to achieve complete laboratory functionality on-chip.