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Updated: Jul 15, 2026

Detection of Foodborne Bacterial Pathogens from Individual Filth Flies
Published on: February 13, 2015
[Salmonella meningitis in Ouagadougou, Burkina Faso, from 2000 to 2004]
1Service de bactériologie-virologie, CHU Yalgado-Ouédraogo, 03 BP 7022 Ouagadougou, Burkina Faso. lsangare@univ-ouaga.bf
Abstract:
56 strains of Salmonella were isolated from the cerebro-spinal fluids (CSF) from meningitis suspected patients at the Yalgado-Ouédraogo University hospital center in Burkina Faso, from January 2000 to December 2004. 75% of the patients were less than 3 years old; 71.4% of the CSF were purulent, with an average of 523 leucocytes/mm3 and 78% of neutrophile polynuclears. The strains identified belonged mostly to Salmonella O: 4.5 group (51.8%). In vitro, 92.7% of the strains were resistant to ampicillin and this resistance was partially restored with amoxicillin/clavulanic acid; however no strain was resistant to ceftriaxone. For the overall 56 patients, 20 different antibiotherapy regimes were used and they were successful in only 27% cases while 71% of patients died and 2% escaped from the hospital. Neurologic sequels were found in a patient treated with both ceftriaxone and chloramphenicol. These results showed that the illness occurred mainly in infants and was associated with high mortality rate. Most of the Salmonella strains were multi-drug resistant. In spite of strains multi-antibiotics resistance, adequate definition of therapeutic lines and early treatment including ceftriaxone could lead to higher cure rates and may improve the outcome.
Insights
Salmonella meningitis, primarily affecting infants in Burkina Faso, shows high mortality due to multi-drug resistant strains. Early treatment with ceftriaxone offers improved outcomes despite resistance challenges.
Area of Science:
- Clinical Microbiology
- Infectious Diseases
- Pediatrics
Context:
- Meningitis outbreaks in Burkina Faso
- Salmonella infections in cerebrospinal fluid (CSF)
- High pediatric patient demographic
Purpose:
- Identify Salmonella serogroups causing meningitis
- Assess antibiotic resistance patterns
- Evaluate treatment outcomes and mortality rates
Summary:
- 56 Salmonella strains from CSF of meningitis patients (2000-2004) were analyzed.
- Predominant serogroup was Salmonella O: 4.5; 92.7% of strains showed ampicillin resistance.
- High mortality (71%) observed, with ceftriaxone showing no resistance and potential for improved treatment.
Impact:
- Highlights the significant burden of Salmonella meningitis in infants.
- Underscores the challenge of multi-drug resistant Salmonella strains.
- Recommends ceftriaxone as a critical therapeutic option for better patient outcomes.
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