[Salmonella meningitis in Ouagadougou, Burkina Faso, from 2000 to 2004]

L Sangaré1, M Kienou, P Lompo

  • 1Service de bactériologie-virologie, CHU Yalgado-Ouédraogo, 03 BP 7022 Ouagadougou, Burkina Faso. lsangare@univ-ouaga.bf

Insights

Salmonella meningitis, primarily affecting infants in Burkina Faso, shows high mortality due to multi-drug resistant strains. Early treatment with ceftriaxone offers improved outcomes despite resistance challenges.

Area of Science:

  • Clinical Microbiology
  • Infectious Diseases
  • Pediatrics

Context:

  • Meningitis outbreaks in Burkina Faso
  • Salmonella infections in cerebrospinal fluid (CSF)
  • High pediatric patient demographic

Purpose:

  • Identify Salmonella serogroups causing meningitis
  • Assess antibiotic resistance patterns
  • Evaluate treatment outcomes and mortality rates

Summary:

  • 56 Salmonella strains from CSF of meningitis patients (2000-2004) were analyzed.
  • Predominant serogroup was Salmonella O: 4.5; 92.7% of strains showed ampicillin resistance.
  • High mortality (71%) observed, with ceftriaxone showing no resistance and potential for improved treatment.

Impact:

  • Highlights the significant burden of Salmonella meningitis in infants.
  • Underscores the challenge of multi-drug resistant Salmonella strains.
  • Recommends ceftriaxone as a critical therapeutic option for better patient outcomes.

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