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Updated: Jul 15, 2026
09:27
DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning
Published on: March 15, 2011
Normalization of dye bias in microarray data using the mixture of splines model
Yongsung Joo1, George Casella, James Booth
1University of Florida, USA. yjoo@phhp.ufl.edu
Abstract:
This paper discusses characteristics of dye biases in microarray data that the conventional normalization methods do not handle, and proposes a new normalization method involving a mixture of splines model. We also develop a test for between-group comparisons of each gene that is designed to be used with our proposed method.
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The chi-square test was developed by Pearson in 1990.
The first step of performing a Chi-square analysis is to establish a null hypothesis, which assumes that there is no real...