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A guide to murine coagulation factor structure, function, assays, and genetic alterations.
J J Emeis1, M Jirouskova, E-M Muchitsch
1Vascular and Metabolic Diseases, TNO--Prevention and Health, Leiden, The Netherlands.
Journal of Thrombosis and Haemostasis : JTH
|April 4, 2007
Summary
Murine (mouse) blood coagulation is similar to human. Studies on mouse hemostasis offer insights into human blood clotting and thrombosis models.
Area of Science:
- Hematology
- Hemostasis and Thrombosis Research
Background:
- Murine blood coagulation factors and function closely resemble human counterparts.
- Mice are adaptable to genetic manipulation, facilitating extensive study of coagulation.
- Murine models provide significant insights into human hemostasis and thrombosis.
Purpose of the Study:
- To provide a comprehensive reference for investigators studying hemostasis and thrombosis.
- To summarize the literature on murine coagulation factor structure, function, and assays.
- To offer recommendations for obtaining, processing, and assaying mouse blood hemostatic components.
Main Methods:
- Review of extensive literature on murine coagulation.
- Summary of murine coagulation factor structure and function.
- Compilation of data on murine coagulation assays and genetic alterations.
Main Results:
- Murine studies have yielded significant insights into human hemostasis.
- Mouse models are valuable for evaluating thrombosis pathophysiology and treatment.
- Established protocols for hemostatic component analysis in mice.
Conclusions:
- Murine models are essential tools for advancing hemostasis and thrombosis research.
- This review serves as a vital resource for researchers in the field.
- Understanding murine coagulation aids in developing human therapeutic strategies.
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