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A possible mosaic form of delayed centromere separation and aneuploidy
1Department of Paediatrics, University Medical School of Pécs, Hungary.
Human Genetics
|February 1, 1992
Abstract:
On average, a "normal" centromere separation sequence was seen in 3 neonates with trisomy 18 and in their parents. When evaluating individual mitoses, unusually late separating chromosomes 18 were found in a few cells of one of the parents in each family. A possible germline mosaicism of delayed separation in the parent may account for trisomy in the offspring.