The association of chronic endometritis with preterm birth

The purpose of this study was to determine whether chronic endometritis (CE) that is diagnosed by endometrial biopsy is associated with preterm birth at <37 weeks of gestation.

Pathology reports for women aged 18-45 years who underwent clinically indicated endometrial biopsy between 1992 and 2002 were solicited from 3 participating clinical pathology laboratories. Reports were dichotomized into those with and those without CE by a standard definition. Results were linked to birth certificates at the Ohio Department of Health. Women who delivered singleton infants (1992-2002) within 3 years of biopsy were included. Biopsy specimens that were obtained from women with conditions that were associated with indicated preterm birth were excluded. Statistical analysis included logistic regression, Student's t-test, Fisher's exact test, and chi-square test, where appropriate. A probability value of <.05 was considered significant.

The 1603 endometrial biopsy reports were identified and forwarded. The Ohio Department of Health linked birth certificate data to 193 reports, 157 of which met inclusion criteria and comprised the study group. Twenty-six of 157 women (16.6%) who were studied had CE. The odds of delivering at <37 weeks of gestation were not significantly higher for women with CE (odds ratio, 2.51; 95% CI, 0.86-7.29; P = .091). Infants who were born at <37 weeks of gestation were more likely to be black (P < .001); to have intrapartum fever, meconium, or fetal distress (P = .026) and to require assisted ventilation (P = .016).

In our study group, women with CE were not more likely to deliver an infant at <37 weeks of gestation.