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Monitoring Neuronal Survival via Longitudinal Fluorescence Microscopy

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Published on: January 19, 2019

TRAIL signalling: decisions between life and death.

Christina Falschlehner¹, Christoph H Emmerich, Björn Gerlach

¹Division of Apoptosis Regulation (D040), Tumor Immunology Program, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.

The International Journal of Biochemistry & Cell Biology

|April 4, 2007

Summary

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively kills cancer cells, making it a promising biotherapeutic. This review details TRAIL

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Area of Science:

Molecular Biology
Cell Biology
Cancer Research

Background:

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in tumor cells.
TRAIL and agonistic antibodies targeting TRAIL-R1/TRAIL-R2 are promising cancer therapeutics.
TRAIL receptors include apoptosis-inducing (TRAIL-R1, TRAIL-R2) and non-apoptosis-inducing (TRAIL-R3, TRAIL-R4) types.

Purpose of the Study:

To review the signaling pathways initiated by TRAIL receptors.
To elucidate the interplay between apoptosis and non-apoptosis signaling in TRAIL pathways.
To summarize key findings on the TRAIL signaling network and its role in tumor cell fate.

Main Methods:

Review of existing literature on TRAIL signaling pathways.
Analysis of the formation and function of the TRAIL death-inducing signaling complex (DISC).
Examination of the interaction between extrinsic (TRAIL-mediated) and intrinsic apoptosis pathways.

Main Results:

DISC formation triggers a protease cascade leading to apoptosis.
TRAIL signaling involves crosstalk between extrinsic and intrinsic apoptosis pathways.
NF-kappaB, PKB/Akt, and MAPK pathways modulate both apoptotic and non-apoptotic TRAIL signaling.

Conclusions:

TRAIL-mediated apoptosis is a complex process involving multiple signaling pathways.
Understanding TRAIL signaling networks is crucial for developing effective cancer therapies.
The balance between apoptotic and non-apoptotic signaling determines tumor cell survival or death.