Related Experiment Video

Updated: Jul 15, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

microRNAs and cancer: role in tumorigenesis, patient classification and therapy

E Hernando1

  • 1Experimental Pathology Program, Department of Pathology, New York University School of Medicine, New York 10016, USA. eva.hernando@med.nyu.edu

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|April 4, 2007
PubMed

Insights

MicroRNAs (miRNAs) are small RNAs crucial for cell processes and cancer development. miRNA profiling accurately classifies tumors and predicts outcomes, offering new diagnostic and therapeutic strategies for cancer patients.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression in vital cellular functions.
  • Emerging evidence implicates miRNAs in the initiation and progression of human cancers.
  • miRNA expression patterns are altered in various malignancies.

Purpose of the Study:

  • To review the role of miRNAs in cancer pathogenesis.
  • To discuss miRNA profiling studies in human malignancies.
  • To explore the diagnostic and therapeutic implications of miRNAs in cancer care.

Main Methods:

  • Literature review of functional studies and high-throughput profiling data.
  • Analysis of miRNA roles as tumor suppressors and oncogenes.
  • Examination of miRNA profiling for tumor classification and outcome prediction.

Main Results:

  • miRNAs are key regulators in crucial cell processes like apoptosis and differentiation.
  • miRNAs play significant roles in both the initiation and progression of cancers.
  • miRNA profiling demonstrates high accuracy in classifying tumors and predicting patient prognosis.

Conclusions:

  • miRNAs are critical players in cancer development and progression.
  • miRNA profiling holds substantial promise for cancer diagnosis and patient outcome prediction.
  • Targeting miRNAs may offer novel therapeutic strategies for cancer treatment.

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