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Function and localization within rostral prefrontal cortex (area 10).

Paul W Burgess1, Sam J Gilbert, Iroise Dumontheil

  • 1UCL Institute of Cognitive Neuroscience and Psychology Department, University College London, 17 Queen Square, London WC1E 6BT, UK. p.burgess@psychol.ucl.ac.uk

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|April 4, 2007
PubMed
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The rostral prefrontal cortex (PFC), specifically area 10, acts as a gateway controlling attention. It directs focus either externally to sensory input (stimulus-oriented attending) or internally to self-generated thoughts (stimulus-independent attending).

Area of Science:

  • Cognitive Neuroscience
  • Neuroimaging
  • Prefrontal Cortex Function

Background:

  • The rostral prefrontal cortex (PFC), approximating area 10, is implicated in complex cognitive functions.
  • Understanding the functional organization of area 10 is crucial for interpreting neuroimaging studies.
  • Previous research suggests distinct roles for different subregions of area 10.

Purpose of the Study:

  • To propose and provide evidence for the 'gateway hypothesis' of rostral prefrontal cortex function.
  • To elucidate the role of area 10 in mediating stimulus-oriented (SO) and stimulus-independent (SI) attending.
  • To establish a general principle for functional imaging studies of area 10.

Main Methods:

  • Design and performance of novel cognitive tasks to probe SO and SI attending.

Related Experiment Videos

  • Analysis of brain activation patterns in area 10 during these tasks.
  • Meta-analysis of existing neuroimaging data to validate behavioral-activation predictions.

    • Main Results:

    • Novel tasks revealed predicted activation patterns in area 10 related to SO and SI attending.
    • Established cognitive functions, such as prospective and context memory, showed activations consistent with the gateway hypothesis.
    • Meta-analysis confirmed that behavior-activation patterns within rostral PFC support the proposed attentional system across diverse tasks.

    Conclusions:

    • The gateway hypothesis provides a unifying framework for understanding area 10's role in attention.
    • Medial area 10 supports SO attending, while lateral area 10 supports SI attending.
    • Further functional dissociations exist within medial area 10, distinguishing anterior (SO attending) and caudal (mentalizing) regions.