Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Islet cell transplantation.

P Srinivasan1, G C Huang, S A Amiel

  • 1King's College London School of Medicine at King's College Hospital, Institute of Liver Studies and Diabetes Research Group, King's College Hospital, London, UK.

Postgraduate Medical Journal
|April 4, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Secondary neutron emissions and induced activity quantification during 14 MeV proton irradiation of thick natural yttrium target.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2026
Same author

Molecular Characterization and Detection of <i>Brachyspira pilosicoli</i> Associated with Intestinal Dysbiosis of Layer Chickens on the Indian Subcontinent.

Avian diseases·2026
Same author

Phytochemical-Mediated Synthesis of AgNPs Using Caulerpa peltata: Photoluminescent Analysis and Cytotoxic Potential.

Luminescence : the journal of biological and chemical luminescence·2025
Same author

Phyco-Fabricated Zinc Oxide Nanorods From Dictyota dichotoma Seaweed: A Promising Resource for Environmental and Biomedical Applications.

Luminescence : the journal of biological and chemical luminescence·2025
Same author

Green Synthesis of ZrO<sub>2</sub> Nanoparticles From Gardenia resinifera for Efficient Photocatalytic Methylene Blue Dye Degradation With Antimicrobial and Antioxidant Properties.

Luminescence : the journal of biological and chemical luminescence·2025
Same author

Fabrication and Characterization of Zinc Oxide Nanoparticles Derived From Aegle marmelos Fruit: Evaluation of Antioxidant, Antibacterial, and Photocatalytic Properties.

Luminescence : the journal of biological and chemical luminescence·2025
Same journal

Dapagliflozin-induced anaphylactic shock.

Postgraduate medical journal·2026
Same journal

Comparative efficacy of Janus kinase inhibitors in severe alopecia areata: a network meta-analysis based on randomized controlled trials.

Postgraduate medical journal·2026
Same journal

Two cases of toxic epidermal necrolysis with severe ocular involvement treated with adjunctive tofacitinib.

Postgraduate medical journal·2026
Same journal

Diastolic dysfunction and diabetes: the DIADAD study-a retrospective cohort study from Liverpool.

Postgraduate medical journal·2026
Same journal

Care, cash, and proof: forensic accountability for war-related starvation.

Postgraduate medical journal·2026
Same journal

Response to traumatic injuries in polo players in England.

Postgraduate medical journal·2026
See all related articles

Islet cell transplantation offers hope for type 1 diabetes, but long-term insulin independence is often lost. Patients with severe hypoglycemia benefit most from this procedure.

Area of Science:

  • Endocrinology
  • Transplantation immunology
  • Metabolic disorders

Background:

  • Type 1 diabetes management often involves challenges with glycemic control.
  • Normal exocrine pancreatic function in type 1 diabetes supports islet cell transplantation.
  • Whole organ pancreas transplantation has limitations, driving interest in alternatives.

Purpose of the Study:

  • To review the history and evolution of islet cell transplantation for type 1 diabetes.
  • To assess the long-term outcomes and indications for islet cell transplantation.
  • To discuss current clinical trials and future challenges in the field.

Main Methods:

  • Review of historical data and clinical trial outcomes.
  • Analysis of islet isolation techniques and transplant procedures.

Related Experiment Videos

  • Evaluation of immunosuppressive strategies and patient selection criteria.

    • Main Results:

    • Islet cell transplantation can achieve insulin independence in selected type 1 diabetes patients.
    • Long-term insulin independence may decline over time, though glycemic stability can be maintained.
    • Patients experiencing severe hypoglycemia benefit most from islet cell transplantation.

    Conclusions:

    • Islet cell transplantation is a promising option for type 1 diabetes, particularly for those with severe hypoglycemia.
    • Further research is needed to improve long-term graft survival and insulin independence.
    • Optimizing immunosuppression and patient selection are key to advancing this therapy.