Related Experiment Video

Updated: Jul 15, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Late stent thrombosis associated with coronary aneurysm formation after sirolimus-eluting stent implantation

Shahid Aziz1, John L Morris, Raphael A Perry

  • 1Department of Cardiology, Royal Blackburn Hospital, Blackburn, United Kingdom. saziz1@btinternet.com

The Journal of Invasive Cardiology
|April 4, 2007
PubMed

Insights

Late stent thrombosis occurred 26 months after sirolimus-eluting stent (SES) implantation, despite dual antiplatelet therapy. This rare complication involved positive vessel remodeling and coronary aneurysm formation.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Stent thrombosis remains a critical complication following coronary stent implantation.
  • Late stent thrombosis after drug-eluting stent (DES) deployment raises concerns about long-term safety.
  • Sirolimus-eluting stents (SES) are widely used, necessitating understanding of their long-term performance.

Observation:

  • A case of late stent thrombosis is presented, occurring 26 months post-sirolimus-eluting stent (SES) implantation.
  • The event was associated with significant positive vessel remodeling.
  • Coronary aneurysm formation was observed in the stented arterial segment.

Findings:

  • Late stent thrombosis can occur even with dual antiplatelet therapy.
  • Positive vessel remodeling and coronary aneurysm formation are potential sequelae of SES implantation.
  • The Cypher SES (Cordis Corp.) was implicated in this late stent thrombosis event.

Implications:

  • This case highlights the importance of continued surveillance for late stent thrombosis, even years after DES implantation.
  • Understanding the mechanisms of positive vessel remodeling and aneurysm formation is crucial for improving stent design and patient outcomes.
  • Further research is needed to optimize antiplatelet strategies and identify patients at higher risk for late stent thrombosis.

Related Concept Videos

Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...