Related Experiment Videos

[Role of matrix metalloproteinase-3 in joint destruction in rheumatoid arthritis]

Eiji Sugiyama1

  • 1University of Toyama, Graduate school of Medicine and Pharmaceutical Sciences for Research.

Clinical Calcium
|April 4, 2007
PubMed

Insights

Matrix metalloproteinase-3 (MMP-3), induced by inflammatory cytokines, degrades cartilage and drives rheumatoid joint destruction. Elevated serum MMP-3 levels are useful markers for rheumatoid arthritis disease activity and predicting joint damage.

Area of Science:

  • Biochemistry
  • Immunology
  • Rheumatology

Context:

  • Rheumatoid arthritis involves inflammatory cytokines like interleukin-1 and tumor necrosis factor-alpha in the synovium.
  • Matrix metalloproteinase-3 (MMP-3) is upregulated by these cytokines in rheumatoid synovium.

Purpose:

  • To review the role of MMP-3 in the joint destruction characteristic of rheumatoid arthritis.
  • To discuss the clinical utility of serum MMP-3 levels as a laboratory marker in rheumatoid arthritis.

Summary:

  • MMP-3 degrades extracellular matrix components in cartilage, playing a key role in rheumatoid joint destruction.
  • Serum MMP-3 levels serve as a clinically valuable indicator for predicting joint destruction and assessing disease activity in rheumatoid arthritis.

Impact:

  • Understanding MMP-3's role can inform therapeutic strategies targeting joint destruction in rheumatoid arthritis.
  • Serum MMP-3 measurement offers a practical tool for monitoring rheumatoid arthritis progression and treatment response.

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
A...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...