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Updated: Jul 15, 2026
08:01
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
Published on: February 28, 2017
The Notch1/c-Myc pathway in T cell leukemia
Vishva Mitra Sharma1, Kyle M Draheim, Michelle A Kelliher
1Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Cell Cycle (Georgetown, Tex.)
|April 4, 2007
Summary
The Notch1 pathway directly regulates c-Myc, driving cancer growth. This Notch1-c-Myc signaling is crucial for leukemia and mammary tumor development, offering therapeutic targets.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Notch signaling is frequently deregulated in human cancers.
- The oncogenic roles of Notch1 and c-Myc are well-established.
- A direct link between Notch1 and c-Myc was previously uncharacterized.
Purpose of the Study:
- To investigate the direct transcriptional relationship between Notch1 and c-Myc.
- To determine the role of the Notch1-c-Myc pathway in cancer cell growth and survival.
- To provide evidence for the contribution of Notch1-c-Myc signaling in tumorigenesis.
Main Methods:
- Identification of c-Myc as a direct transcriptional target of Notch1 in T cell acute lymphoblastic leukemia (T-ALL).
- Analysis of leukemic cell lines to assess dependence on the Notch1-c-Myc pathway.
- Genetic studies in mouse models of mammary tumorigenesis.
Main Results:
- c-Myc was identified as a direct transcriptional target of the Notch1 pathway.
- Leukemic cell growth and survival in mouse tal1 tumor models were dependent on the Notch1-c-Myc pathway.
- Genetic evidence confirmed the Notch1-c-Myc pathway's contribution to mouse mammary tumorigenesis.
Conclusions:
- Notch1 directly regulates c-Myc expression.
- The Notch1-c-Myc pathway is essential for sustaining leukemic cell growth and survival.
- Notch1 contributes to T cell and epithelial cell transformation, at least in part, by maintaining c-Myc levels.
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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
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Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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