Related Experiment Video
Updated: Jul 15, 2026
10:21
Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
HOX deregulation in acute myeloid leukemia
1Division of Hematology/Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
The Journal of Clinical Investigation
|April 4, 2007
Summary
Caudal-type homeobox transcription factor 2 (CDX2) is overexpressed in most acute myeloid leukemia (AML) cases. This finding offers a new explanation for HOX gene deregulation in AML and provides insights into leukemogenesis.
Area of Science:
- Hematology
- Molecular Biology
- Cancer Research
Background:
- Homeobox (HOX) gene deregulation is implicated in acute myeloid leukemia (AML).
- HOX gene overexpression in AML has been linked to chromosomal abnormalities and mixed-lineage leukemia (MLL) involvement.
- The precise regulatory mechanisms driving HOX gene dysregulation in AML require further elucidation.
Purpose of the Study:
- To investigate the role of caudal-type homeobox transcription factor 2 (CDX2) in acute myeloid leukemia (AML).
- To explore CDX2 as an alternative mechanism for HOX gene deregulation and leukemogenesis in AML.
- To understand the hierarchy of HOX gene regulation in the context of AML.
Main Methods:
- Analysis of CDX2 expression in a cohort of AML patients.
- Utilizing murine models to assess the leukemogenic potential of CDX2 overexpression.
- Investigating the impact of CDX2 on HOX gene expression.
Main Results:
- Caudal-type homeobox transcription factor 2 (CDX2) was found to be overexpressed in 90% of AML patients studied.
- Overexpression of CDX2 in murine models induced transplantable AML.
- CDX2 influences HOX gene expression, suggesting a role in leukemogenesis.
Conclusions:
- CDX2 overexpression presents an alternative mechanism for HOX gene-induced leukemogenesis in AML.
- CDX2 plays a significant role in the hierarchy of HOX gene regulation within AML.
- These findings offer new therapeutic targets for AML treatment.
Related Concept Videos
02:33Hedgehog Signaling Pathway
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
01:24Regulation of Angiogenesis and Blood Supply
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
01:19Multipotency of Hematopoietic Stem Cells
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
01:21Lineage Commitment
Commitment is the process whereby stem cells:
01:15Differentiation of Common Myeloid Progenitor Cells
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
01:01Regulation of Hematopoietic Stem Cells
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...