IL-4 inducibility in NKT cells, naïve CD4+ T cells and TCR-gamma delta T cells
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Updated: Jul 15, 2026

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
Published on: April 16, 2015
1Institute of Molecular Biology, Academia Sinica, 128, 2nd Section, Academy Road, Nankang District, Taipei, 11529, Taiwan.
Abstract:
NKT cells, naïve CD4(+) T cells, and TCR-gammadelta T cells belong to distinct T cell lineages but all express T cell receptors generated through random combinatorial joining of V-(D)-J genes. These distinct lineage T cells also possess the property of promptly activating the IL-4 gene upon T cell receptor stimulation. A comparative accounting of features as they pertain to IL-4 inducibility in these three distinct lineage T cells is provided here.
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