[Monomeric Indole Alkaloids from Kopsia officinalis.]
1Institut de Matière Médicale, Académie Chinoise des Sciences Médicales, Pékin, Chine.
Planta Medica
|August 1, 1983
Summary
Researchers identified ten indole alkaloids from KOPSIA OFFICINALIS roots, including six novel compounds. This discovery expands the known chemical diversity of this plant species.
Area of Science:
- Natural Products Chemistry
- Phytochemistry
Context:
- The plant KOPSIA OFFICINALIS is a source of complex indole alkaloids.
- Previous research has documented various alkaloids from this species.
Purpose:
- To isolate and characterize monomeric indole alkaloids from the roots of KOPSIA OFFICINALIS.
- To identify novel alkaloid structures and expand the chemical knowledge of the plant.
Summary:
- Ten monomeric indole alkaloids were identified from KOPSIA OFFICINALIS roots.
- Four known alkaloids: (-)-kopsinine, (+)-5,22-dioxokopsane, (-)-tetrahydroalstonine, and (-)-quebrachamine.
- Six new alkaloids: (-)-isoeburnamine, (-)-N-methoxycarbonyl-12-methoxykopsinaline, (-)-N-methoxycarbonyl-11,12-methylenedioxykopsinaline, (-)-N-methoxycarbonyl-11,12-dimethoxykopsinaline, (-)-11,12-methylenedioxykopsinaline, and (-)-12-methoxykopsinaline.
Impact:
- Contributes to the understanding of indole alkaloid biosynthesis and diversity.
- Provides new chemical entities for potential pharmacological investigation.
- Enhances the phytochemical database of KOPSIA OFFICINALIS.
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