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Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
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Related Experiment Video

Updated: Jul 15, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
09:50

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade

Published on: August 14, 2019

New Flavanones from Prosopis juliflora Roots.

S Malhotra1, K Misra

  • 1Chemical Laboratories, University of Allahabad, Allahabad, India.

Planta Medica
|January 1, 1983
PubMed
Summary

Two novel flavanone glycosides were identified from Prosopis juliflora root extract. These compounds, characterized using chemical analysis, expand our understanding of plant-derived bioactive molecules.

Area of Science:

  • Phytochemistry
  • Natural Product Chemistry
  • Organic Chemistry

Background:

  • Prosopis juliflora is a plant species with a history of traditional medicinal use.
  • The chemical constituents of P. juliflora roots are not fully elucidated.
  • Flavonoids are a class of plant secondary metabolites known for diverse biological activities.

Purpose of the Study:

  • To isolate and characterize new chemical compounds from the roots of Prosopis juliflora.
  • To contribute to the phytochemical knowledge of the Prosopis genus.
  • To identify novel flavanone glycosides for potential further investigation.

Main Methods:

  • Extraction of P. juliflora roots using ethanol.
  • Fractionation of the ethanolic extract using benzene and ethyl acetate.

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  • Isolation and purification of compounds using chromatographic techniques.
  • Structure elucidation of isolated compounds using spectroscopic methods (e.g., NMR, MS).

    • Main Results:

    • Two new flavanone glycosides were successfully isolated from the specified fractions.
    • Compound I was characterized as 3', 4'-dihydroxy 5-methoxy 6-methyl flavanone 7-O-beta-D-glucopyranoside.
    • Compound II was characterized as 7,4'-dimethoxy 6,8-dimethyl flavanone 5-O-beta-D-galactopyranoside.

    Conclusions:

    • The study successfully identified and characterized two previously unknown flavanone glycosides from Prosopis juliflora roots.
    • The findings enhance the understanding of the phytochemical profile of Prosopis juliflora.
    • These novel compounds represent potential leads for future research into their biological activities and applications.