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Updated: Jul 15, 2026
08:08
Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
Published on: February 27, 2015
Mass spectrometry-based "omics" technologies in cancer diagnostics
Xuewu Zhang1, Dong Wei, Yeeleng Yap
1College of Light Industry and Food Sciences, South China University of Technology, Guangzhou, China. snow_dance@sina.com
Mass Spectrometry Reviews
|April 4, 2007
Summary
Mass spectrometry-based omics techniques offer promising avenues for biomarker discovery and early cancer diagnosis. While not yet clinically ready, omics-based diagnostics are expected to supplement cancer care within a decade.
Area of Science:
- Biomedical Sciences
- Analytical Chemistry
- Oncology
Background:
- Numerous "omics" techniques are crucial for identifying biomarkers and enabling early detection of human cancers.
- Mass spectrometry (MS)-based "omics" approaches are widely employed for molecular diagnosis across diverse biological samples.
Purpose of the Study:
- To comprehensively review mass spectrometry-based "omics" applications in the molecular diagnosis of human cancers.
- To discuss current and potential challenges, solutions, and future prospects of these diagnostic approaches.
Main Methods:
- Review of mass spectrometry-based "omics" methodologies.
- Analysis of various biological samples for cancer diagnosis.
- Discussion of experimental and bioinformatic challenges and solutions.
Main Results:
- "Omics" techniques show significant potential for biomarker discovery and early cancer diagnosis.
- Mass spectrometry-based approaches are versatile tools for molecular cancer diagnostics.
Conclusions:
- Current "omics" diagnostic tools are in early stages and not yet ready for immediate clinical application.
- "Omics"-based cancer diagnostics are anticipated to become a valuable supplement to existing clinical methods within the next 10 years.
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