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Gliosarcoma with infratemporal fossa extension. Case report.

Burak Sade¹, Richard A Prayson, Joung H Lee

¹Brain Tumor Institute, and Department of Neurosurgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

Journal of Neurosurgery

|April 5, 2007

Summary

This case study highlights a rare temporal lobe gliosarcoma with skull base extension. Aggressive surgical resection and adjuvant therapy led to a recurrence-free outcome, emphasizing gliosarcoma as a differential diagnosis for complex brain tumors.

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Area of Science:

Neuro-oncology
Skull Base Surgery
Neurosurgery

Background:

Gliosarcomas are typically intraaxial brain tumors.
Skull base involvement in gliosarcoma is exceptionally rare.

Observation:

A 55-year-old male presented with headache and papilledema.
MRI revealed a temporal lobe mass with infratemporal fossa extension.
The tumor had both intraaxial and extracranial components.

Findings:

Gross-total resection was achieved via frontotemporal craniotomy and skull base techniques.
Histopathology confirmed gliosarcoma.
The patient remained recurrence-free for 12 months post-treatment with radiotherapy and temozolomide.

Implications:

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Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Published on: August 15, 2025

Gliosarcoma should be considered in cases of intraaxial and extracranial mass lesions.
Skull base surgical techniques are crucial for optimal outcomes in such rare presentations.
Further research is needed to understand the impact of skull base involvement on gliosarcoma prognosis.