Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electrical synapses in basal ganglia.

Marie Vandecasteele1, Jean-Michel Deniau, Jacques Glowinski

  • 1Dynamique et Pathophysiologie des Réseaux Neuronaux, INSERM U667, Collège de France.

Reviews in the Neurosciences
|April 5, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transient pores account for cell-penetrating peptide and homeoprotein translocation.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events.

Science advances·2026
Same author

Deep Brain Stimulation restores information processing in parkinsonian cortical networks.

medRxiv : the preprint server for health sciences·2024
Same author

Actomyosin-mediated inhibition of synaptic vesicle release under CB<sub>1</sub>R activation.

Translational psychiatry·2024
Same author

Anti-Hebbian plasticity drives sequence learning in striatum.

Communications biology·2024
Same author

Synaptic plasticity through a naturalistic lens.

Frontiers in synaptic neuroscience·2023

Electrical synapses, or neuronal coupling, are crucial for neural oscillations in the basal ganglia (BG). This review explores their presence and function in the striatum and substantia nigra pars compacta (SNc), impacting goal-directed behavior.

Area of Science:

  • Neuroscience
  • Cellular and Molecular Neuroscience

Background:

  • The basal ganglia (BG) are critical for organizing goal-directed behaviors.
  • Dysfunction in the BG is linked to motor and cognitive impairments, as seen in Parkinson's disease.
  • Neural oscillations and synchronization are increasingly recognized for their role in BG function and dysfunction.

Purpose of the Study:

  • To review the presence and functionality of electrical synapses in the basal ganglia.
  • To investigate the putative role of electrical synapses in the striatum and substantia nigra pars compacta (SNc).
  • To highlight the importance of neuronal coupling in BG network dynamics.

Main Methods:

  • Literature review of studies on electrical synapses and neuronal coupling in the basal ganglia.
  • Focus on experimental evidence from the striatum and substantia nigra pars compacta (SNc).

Related Experiment Videos

  • Analysis of the functional properties and implications of electrical synapses.

    • Main Results:

    • Electrical synapses (neuronal coupling) are present in the basal ganglia.
    • These connections contribute to emergent patterns of neural activity, such as oscillations.
    • The striatum and substantia nigra pars compacta (SNc) show well-documented evidence of neuronal coupling.

    Conclusions:

    • Electrical synapses play a significant role in the normal and pathological function of the basal ganglia.
    • Understanding neuronal coupling is essential for deciphering BG network dynamics and associated disorders.
    • Further research into electrical synapses may offer new therapeutic targets for BG-related diseases.