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Changes in bronchial responsiveness following nasal provocation with allergen
J Corren1, A D Adinoff, C G Irvin
1National Jewish Center for Immunology and Respiratory Medicine, Department of Medicine and Pediatrics, Denver, Colo.
The Journal of Allergy and Clinical Immunology
|February 1, 1992
Summary
Nasal allergen challenges in asthma patients did not cause lower airway dysfunction. However, allergic rhinitis did increase bronchial responsiveness to methacholine, suggesting a link between upper and lower airway sensitivity.
Area of Science:
- Allergy and Immunology
- Pulmonary Medicine
- Respiratory Research
Background:
- The link between upper airway inflammation (allergic rhinitis) and asthma is debated.
- Asthma patients with a history of exacerbations following allergic rhinitis onset were selected for this study.
Purpose of the Study:
- To investigate the relationship between allergic rhinitis and lower airway dysfunction.
- To determine if nasal allergen challenge impacts bronchial responsiveness in asthma patients.
Main Methods:
- Double-blind, randomized nasal challenges with allergen or placebo were performed.
- Nasal provocation techniques limited allergen delivery to the nose.
- Lung function (FEV1, specific conductance, lung volumes, peak flow) and bronchial responsiveness to methacholine were measured.
Main Results:
- No significant changes in airflow limitation (FEV1, specific conductance, lung volumes, peak flow) were observed post-nasal allergen challenge.
- A significant relative increase in bronchial responsiveness to methacholine was noted 30 minutes and 4.5 hours after nasal allergen challenge compared to placebo.
Conclusions:
- Nasal allergic responses do not directly induce airflow limitation in the lower airways of asthma patients.
- Allergic rhinitis can alter bronchial responsiveness, suggesting an indirect link to lower airway sensitivity.
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