Related Experiment Videos
Positron emission tomography and familial Alzheimer's disease: a pilot study
B H Guze1, J M Hoffman, J C Mazziotta
1Department of Radiological Sciences, UCLA.
Objective:
Local cerebral metabolic rates for glucose were compared between patients with familial Alzheimer's disease (FAD), sporadic Alzheimer's Disease (SAD), and normal controls (NC) to determine if FAD is associated with a unique pattern of brain metabolism.
Design:
Case-control study matched to convenience sample of FAD.
Methods:
Subjects in the three diagnostic groups were scanned using fluorodeoxyglucose and the Positron Emission Tomographic (PET) technique. The criterion standard of a detailed clinical history and examination were compared to scan results.
Setting:
Patients in a university hospital.
Subjects:
Ambulatory controls and Alzheimer's patients, both sporadic (n = 8) and familial (n = 7). The two groups were similar in severity of cognitive dysfunction.
Results:
FAD and SAD patients did not significantly differ in terms of local cerebral metabolic rates for glucose.