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Chemical Triphosphorylation of Oligonucleotides
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Chemical Triphosphorylation of Oligonucleotides

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Phosphine containing oligonucleotides for the development of metallodeoxyribozymes

Loïc Ropartz1, Nico J Meeuwenoord, Gijsbert A van der Marel

  • 1School of Chemistry, University of St. Andrews, St. Andrews, Fife, UK. pcjk@st-andrews.ac.uk

Chemical Communications (Cambridge, England)
|April 5, 2007
PubMed

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The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
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