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Related Experiment Video

Updated: Jul 15, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Estrogen metabolism modulates bone density in men.

N Napoli¹, R Faccio, V Shrestha

¹Division of Bone and Mineral Diseases, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. nnapoli@im.wustl.edu

Calcified Tissue International

|April 5, 2007

Summary

Estrogen metabolism impacts bone mineral density (BMD) in men. Higher levels of active estrogen metabolites, like 16alpha-hydroxyestrone, are linked to increased proximal femur BMD, suggesting a key role in male bone health.

Related Experiment Videos

Last Updated: Jul 15, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Area of Science:

Endocrinology
Bone Biology
Metabolomics

Background:

Estrogen is crucial for bone homeostasis in men, yet its metabolism's role in male bone health is understudied.
Understanding estrogen metabolism pathways is vital for addressing bone health in aging males.

Purpose of the Study:

To investigate the association between estrogen hydroxylation metabolites and bone mineral density (BMD) in healthy Caucasian males.
To identify specific estrogen metabolites that may predict or influence male BMD.

Main Methods:

Assessed urinary estrogen metabolites (16alpha-hydroxyestrone, estriol, 2-hydroxyestrone, 2-methoxyestrone) using ELISA.
Measured serum estradiol and sex hormone-binding globulin via radioimmunoassay.
Quantified BMD at the lumbar spine and proximal femur using dual-energy X-ray absorptiometry in 61 healthy males.

Main Results:

Active metabolites 16alpha-hydroxyestrone (16alphaOHE(1)) and estriol (E(3)) positively correlated with proximal femur BMD (P < 0.05).
The Free Estradiol Index (FEI) also showed positive correlations with hip, femoral neck, and intertrochanteric BMD (P < 0.05).
16alphaOHE(1), FEI, and BMI were identified as independent predictors of proximal femur BMD via multiple regression analysis.

Conclusions:

Estrogen metabolism significantly modulates bone mineral density in men.
Elevated urinary 16alphaOHE(1) and E(3) levels are associated with higher proximal femur BMD.
16alpha-hydroxyestrone emerges as a key determinant of BMD among evaluated estrogen metabolites in men.