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Angiogenesis in primary central nervous system lymphoma (PCNSL)
Hiroaki Takeuchi1, Ken Matsuda, Ryuhei Kitai
1Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui 910-1193, Japan. takeu@fmsrsa.fukui-med.ac.jp
Journal of Neuro-Oncology
|April 5, 2007
Summary
Vascular endothelial growth factor (VEGF) expression in primary central nervous system lymphoma (PCNSL) is linked to increased microvessel density and better patient survival. Angiogenesis in PCNSL involves VEGF and an absent blood-brain barrier (BBB).
Area of Science:
- Oncology
- Neuroscience
- Pathology
Background:
- Angiogenesis is crucial in malignancy pathogenesis.
- The role of angiogenesis in primary central nervous system lymphoma (PCNSL) is not well understood.
- Vascular endothelial growth factor (VEGF) is a key angiogenic factor.
Purpose of the Study:
- To investigate the clinical and histopathological relevance of angiogenesis in PCNSL.
- To examine the expression of VEGF and microvessel density (MVD) in PCNSL.
- To assess the integrity of the blood-brain barrier (BBB) in PCNSL.
Main Methods:
- Immunohistochemistry and electron microscopy were used.
- VEGF expression in lymphoma cells was evaluated.
- Microvessel density (MVD) was quantified.
- Blood-brain barrier (BBB) markers were assessed.
Main Results:
- MVD was significantly higher in VEGF-positive (VEGF+) PCNSL cases compared to VEGF-negative (VEGF-) cases (P < 0.001).
- VEGF expression correlated significantly with longer patient survival (P < 0.005).
- The BBB was absent in angiogenic vessels of VEGF+ PCNSL but preserved in VEGF- PCNSL.
Conclusions:
- Angiogenesis in PCNSL is associated with VEGF expression and an absent BBB.
- The BBB may be preserved in VEGF- PCNSL, particularly around tumor cells.
- VEGF expression appears to have a prognostic significance in PCNSL.
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