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Related Experiment Video

Updated: Jul 15, 2026

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

Clostridium difficile colitis in solid organ transplantation--a single-center experience.

I Stelzmueller¹, H Goegele, M Biebl

¹Department of General, Thoracic and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria.

Digestive Diseases and Sciences

|April 5, 2007

Summary

Clostridium difficile (CD) infection is a serious complication after solid organ transplantation (SOT). The incidence of CD colitis has significantly increased, with toxic megacolon being a life-threatening concern in SOT recipients.

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Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Area of Science:

Transplantation Medicine
Infectious Diseases
Gastroenterology

Background:

Clostridium difficile (CD) infection is a frequent cause of diarrhea in solid organ transplantation (SOT) recipients.
A retrospective analysis of 2474 SOT procedures identified 43 cases of CD-associated diarrhea between 1996 and 2005.

Observation:

CD infection onset varied widely, from 5 to 2453 days post-transplant, with all patients experiencing abdominal pain and watery diarrhea.
Toxins A and B were confirmed via immunoassay. Treatments included immunosuppression reduction, supportive care, and antibiotics (metronidazole, vancomycin, or both).

Findings:

Toxic megacolon occurred in five patients, necessitating interventions such as colonoscopic decompression or colonic resection.
A notable increase in CD colitis incidence was observed after the year 2000, with 38 of 43 cases occurring post-2000.
One patient died from multiorgan failure following CD enteritis, while others were discharged with functioning grafts.

Implications:

Clostridium difficile colitis is a severe complication following SOT, with a recent dramatic increase in incidence.
The potential for life-threatening toxic megacolon must be recognized and managed promptly in SOT recipients.
Early diagnosis and management are crucial for improving outcomes in SOT patients with CD infection.