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Updated: Jul 15, 2026

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
Published on: June 6, 2025
[Treatment of arterial hypertension]
1Med. Klinik IV, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, Germany. Walter.Zidek@charite.de
Insights
Arterial hypertension, or high blood pressure, is common. Effective treatment lowers cardiovascular risks, with target blood pressure goals varying by individual risk factors and comorbidities.
Area of Science:
- Internal Medicine
- Cardiology
- Hypertension Research
Context:
- Arterial hypertension is the most prevalent internal disease globally.
- Effective management significantly reduces cardiovascular morbidity and mortality.
- Treatment decisions are guided by comprehensive cardiovascular risk assessment.
Purpose:
- To outline current guidelines and strategies for managing arterial hypertension.
- To define target blood pressure goals based on risk stratification.
- To review recommended pharmacologic and non-pharmacologic interventions.
Summary:
- Target blood pressure is generally <140/90 mmHg, lowered to <130/80 mmHg with diabetes mellitus or renal insufficiency.
- Lifestyle modifications are crucial, used alone or with medication.
- First-line pharmacologic agents include diuretics, calcium antagonists, ACE inhibitors, AT1 blockers, and beta blockers, often in combination therapy.
Impact:
- Optimized hypertension management leads to substantial reductions in cardiovascular events.
- Adherence to treatment guidelines improves patient outcomes and quality of life.
- Understanding treatment strategies aids clinicians in personalized patient care.
Abstract:
Arterial hypertension is the most common internal disease. Treatment is highly effective in lowering cardiovascular morbidity and mortality and is indicated based on total cardiovascular risk as assessed by all relevant risk factors. Target blood pressure is <140/90 mmHg, or with concomitant diabetes mellitus or renal insufficiency <130/80 mmHg. Lifestyle modifications are helpful, either alone or as an adjuvant to drug treatment, depending on the severity of the disease. First-line drugs are diuretics, calcium antagonists, ACE inhibitors, AT1 blockers and beta blockers. In most cases, combination therapy is appropriate. Possible treatment strategies include stepped care, initial low-dose combination therapy and sequential monotherapy.
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