Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Periodic Table and Organismal Elements

The Periodic Table and Organismal Elements

Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A high salt intake in early life affects stress-coping response in males but not in female rats.

Physiology & behavior·2024

Same author

A role of Na+, K+ -ATPase in spatial memory deficits and inflammatory/oxidative stress after recurrent concussion in adolescent rats.

Brain research bulletin·2021

Same author

Diphenyl diselenide and cidofovir present anti-viral activity against Bovine Alphaherpesvirus 2 in vitro and in a sheep model.

Research in veterinary science·2020

Same author

Chemical Speciation of Selenium and Mercury as Determinant of Their Neurotoxicity.

Advances in neurobiology·2017

Same author

Anethole improves the in vitro development of isolated caprine secondary follicles.

Theriogenology·2017

Same author

6-Gingerol-rich fraction from Zingiber officinale ameliorates carbendazim-induced endocrine disruption and toxicity in testes and epididymis of rats.

Andrologia·2016

Search research articles

Related Experiment Video

Updated: Jul 15, 2026

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

Published on: January 10, 2025

Heavy metals modulate glutamatergic system in human platelets.

V C Borges¹, F W Santos, J B T Rocha

¹Departamento de Química, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.

Neurochemical Research

|April 5, 2007

Summary

Heavy metals like mercury, cadmium, and lead disrupt glutamate uptake and binding in human platelets, potentially indicating neurotoxicity. These metals also increase oxidative stress, suggesting platelets may serve as biomarkers for heavy metal neurotoxic effects.

More Related Videos

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium

Published on: December 17, 2018

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

Related Experiment Videos

Last Updated: Jul 15, 2026

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies

Published on: January 10, 2025

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium

An Anaerobic Biosensor Assay for the Detection of Mercury and Cadmium

Published on: December 17, 2018

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

Area of Science:

Neuroscience
Toxicology
Biochemistry

Background:

Peripheral tissues offer potential surrogate markers for neural damage and dysfunction.
Platelets share biochemical similarities with neurons, exhibiting parallel changes in central nervous system (CNS) markers.
Heavy metal exposure is a significant public health concern with known neurotoxic effects.

Purpose of the Study:

To investigate the impact of mercury (Hg(2+)), lead (Pb(2+)), and cadmium (Cd(2+)) on glutamate binding and uptake in human platelets.
To explore the role of oxidative stress in heavy metal-induced modulation of the glutamatergic system.

Main Methods:

Human platelets were used to assess the effects of Hg(2+), Pb(2+), and Cd(2+) on [(3)H]-glutamate binding and uptake.
Lipid peroxidation levels and reactive oxygen species (ROS) were measured to evaluate oxidative stress.

Main Results:

Hg(2+), Cd(2+), and Pb(2+) significantly inhibited [(3)H]-glutamate uptake in human platelets.
Hg(2+) inhibited [(3)H]-glutamate binding, whereas Cd(2+) and Pb(2+) stimulated it.
All three heavy metals increased lipid peroxidation and ROS levels in platelets, indicating oxidative stress.

Conclusions:

The glutamatergic system in human platelets is sensitive to heavy metal exposure.
Heavy metals induce oxidative stress in platelets.
Platelets show potential as a biomarker for assessing the neurotoxic effects of heavy metals in humans.