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Published on: January 10, 2014
[Study on the vertical transmission of Y chromosome microdeletions from father to son]
Xiao-bin Zhu1, Zhen Li, An-liang Guo
1Renji Hospital, Shanghai Jiaotong University, Shanghai, 200001 PR China.
Objective:
To analyze the Y chromosome microdeletions in the family of the infertile male and to study on the vertical transmission of Y chromosome microdeletions from father to son.
Methods:
The peripheral blood of infertile patients' family male members was extracted and analyzed with modified multiplex PCR. The infertile family tree was drawn according to the results.
Results:
Two cases in twelve investigated families had azoospermia factor (AZFc) microdeletion heredity. The others had no heredity.
Conclusion:
AZFc microdeletion of the Y chromosome can be transmitted to the male offspring naturally,and the same deletion can result in different phenotypes in different individuals.
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