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[Development of respiratory function in perinatal ontogenesis]

A V Bursian

    Zhurnal Evoliutsionnoi Biokhimii I Fiziologii
    |April 6, 2007
    PubMed

    Insights

    Respiratory rhythm develops through stages in placental animals, from simple contractions to stabilized patterns, influenced by sleep and consciousness. This maturation involves specific neuronal pacemakers and regulatory mechanisms.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Physiology

    Context:

    • Respiratory function development in placental mammals follows a general pattern.
    • Breathing rhythm formation involves transitions from simple contractions to complex patterns with pauses.
    • These patterns are closely linked to sleep-wake states and consciousness.

    Purpose:

    • To propose a concept on the functional maturation sequence and regulatory mechanisms of the respiratory rhythm's central pacemaker.
    • To elucidate the developmental trajectory of respiratory control in mammals.

    Summary:

    • Early respiratory rhythm originates from autogenic activity of neurons in the rostral ventrolateral medulla.
    • Initial regulation relies on direct neuronal sensitivity to chemical environment and neuromodulators.
    • Later stages involve inhibitory control from supramedullary structures and enhanced peripheral receptor influence.

    Impact:

    • Provides a framework for understanding the neurodevelopmental basis of respiratory control.
    • Highlights the interplay between intrinsic neuronal properties and external regulatory inputs in shaping respiratory patterns.
    • Offers insights into the evolution of respiratory regulation across placental mammals.

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