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Updated: Jul 15, 2026
Production and Targeting of Monovalent Quantum Dots
Published on: October 23, 2014
Variables influencing interactions of untargeted quantum dot nanoparticles with skin cells and identification of
Jessica P Ryman-Rasmussen1, Jim E Riviere, Nancy A Monteiro-Riviere
1Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA.
Abstract:
Skin cells (NHEK) take up untargeted quantum dots (QD) with surface polyethylene glycol (PEG), amines, and carboxylic acids, but the mechanisms are unknown. Time courses of QD-NHEK interactions were determined and effects of QD surface coating, temperature, culture medium supplements and inhibitors of the cell cycle and endocytosis identified. The magnitude of QD-NHEK interactions was coating dependent. Low-temperature or unsupplemented medium decreased QD-NHEK interactions. Biochemical inhibitors were identified that attenuate and potentiate QD-NHEK interactions. These results are important for understanding and controlling interactions of untargeted QD with cells.
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